Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia
Pediatric blood & cancer
chemotherapy-induced peripheral neuropathy; motor neuropathy; pediatric acute lymphoblastic leukemia; proxy-reported surveys; sensory neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64-0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54-0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.
Rodwin, Rozalyn L.; DelRocco, Natalie J.; Hibbitts, Emily; Devidas, Meenakshi; Whitley, Moira K.; Mohrmann, Caroline E.; Schore, Reuven J.; Raetz, Elizabeth; Winick, Naomi J.; Hunger, Stephen P.; Loh, Mignon L.; Hockenberry, Marilyn J.; Ma, Xiaomei; Angiolillo, Anne L.; Ness, Kirsten K.; Kairalla, John A.; and Kadan-Lottick, Nina S., "Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia" (2023). GW Authored Works. Paper 3231.