Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia

Rozalyn L. Rodwin, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
Natalie J. DelRocco, Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, Florida, USA.
Emily Hibbitts, Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, Florida, USA.
Meenakshi Devidas, Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Moira K. Whitley, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
Caroline E. Mohrmann, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA.
Reuven J. Schore, Center of Cancer and Blood Disorders, Children's National Health System, Washington, District of Columbia, USA.
Elizabeth Raetz, Department of Pediatrics, NYU Langone Health, New York, New York, USA.
Naomi J. Winick, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Stephen P. Hunger, Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mignon L. Loh, Division of Pediatric Hematology, Oncology, Bone Marrow Transplant and Cellular Therapy, Seattle Children's Hospital and the Ben Towne Center for Childhood Cancer Research, University of Washington, Seattle, Washington, USA.
Marilyn J. Hockenberry, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Xiaomei Ma, Yale Cancer Center, New Haven, Connecticut, USA.
Anne L. Angiolillo, Center of Cancer and Blood Disorders, Children's National Health System, Washington, District of Columbia, USA.
Kirsten K. Ness, Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
John A. Kairalla, Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, Florida, USA.
Nina S. Kadan-Lottick, Cancer Prevention and Control Program, Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.

Document Type

Journal Article

Publication Date

8-17-2023

Journal

Pediatric blood & cancer

DOI

10.1002/pbc.30634

Keywords

chemotherapy-induced peripheral neuropathy; motor neuropathy; pediatric acute lymphoblastic leukemia; proxy-reported surveys; sensory neuropathy

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64-0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54-0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.

Department

Pediatrics

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