The Association of Accelerated Early Growth, Timing of Puberty, and Metabolic Consequences in Children

Authors

Youn Hee Jee, Section on Growth, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Sanjay Jumani, Section on Growth, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Veronica Mericq, Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago 13101, Chile.

Document Type

Journal Article

Publication Date

8-18-2023

Journal

The Journal of clinical endocrinology and metabolism

Volume

108

Issue

9

DOI

10.1210/clinem/dgad202

Keywords

SGA; adrenal; growth; infancy; insulin resistance; puberty

Abstract

Accelerated early growth and early timing of puberty or pubertal variant have been noticed as risk factors for metabolic syndrome, more frequently observed in children born small for gestational age (SGA) or children with premature adrenarche (PA). Children with SGA, especially if they make an accelerated catch-up growth in early life, carry a higher risk for long-term metabolic consequences, such as type 2 diabetes, insulin resistance, and cardiovascular diseases. Furthermore, multiple studies support that these children, either born SGA or with a history of PA, may have earlier pubertal timing, which is also associated with various metabolic risks. This review aims to summarize the recent studies investigating the association between early infantile growth, the timing of puberty, and metabolic risks to expand our knowledge and gain more insight into the underlying pathophysiology.

APA Citation

Jee, Youn Hee; Jumani, Sanjay; and Mericq, Veronica, "The Association of Accelerated Early Growth, Timing of Puberty, and Metabolic Consequences in Children" (2023). GW Authored Works. Paper 3226.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3226

Department

Pediatrics