Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial
Blood pressure; Cardiac arrest; Cardiopulmonary resuscitation; Pediatrics; Pulmonary hypertension
BACKGROUND: Previous studies have identified pulmonary hypertension (PH) as a relatively common diagnosis in children with in-hospital cardiac arrest (IHCA), and preclinical laboratory studies have found poor outcomes and low systemic blood pressures during CPR for PH-associated cardiac arrest. The objective of this study was to determine the prevalence of PH among children with IHCA and the association between PH diagnosis and intra-arrest physiology and survival outcomes. METHODS: This was a prospectively designed secondary analysis of patients enrolled in the ICU-RESUS clinical trial (NCT02837497). The primary exposure was a pre-arrest diagnosis of PH. The primary survival outcome was survival to hospital discharge with favorable neurologic outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged from baseline). The primary physiologic outcome was event-level average diastolic blood pressure (DBP) during CPR. RESULTS: Of 1276 patients with IHCAs during the study period, 1129 index IHCAs were enrolled; 184 (16.3%) had PH and 101/184 (54.9%) were receiving inhaled nitric oxide at the time of IHCA. Survival with favorable neurologic outcome was similar between patients with and without PH on univariate (48.9% vs. 54.4%; p = 0.17) and multivariate analyses (aOR 0.82 [95%CI: 0.56, 1.20]; p = 0.32). There were no significant differences in CPR event outcome or survival to hospital discharge. Average DBP, systolic BP, and end-tidal carbon dioxide during CPR were similar between groups. CONCLUSIONS: In this prospective study of pediatric IHCA, pre-existing PH was present in 16% of children. Pre-arrest PH diagnosis was not associated with statistically significant differences in survival outcomes or intra-arrest physiologic measures.
Morgan, Ryan W.; Reeder, Ron W.; Ahmed, Tageldin; Bell, Michael J.; Berger, John T.; Bishop, Robert; Bochkoris, Matthew; Burns, Candice; Carcillo, Joseph A.; Carpenter, Todd C.; Dean, J Michael; Diddle, J Wesley; Federman, Myke; Fernandez, Richard; Fink, Ericka L.; Franzon, Deborah; Frazier, Aisha H.; Friess, Stuart H.; Graham, Kathryn; Hall, Mark; Hehir, David A.; Himebauch, Adam S.; Horvat, Christopher M.; Huard, Leanna L.; Maa, Tensing; Manga, Arushi; McQuillen, Patrick S.; Meert, Kathleen L.; Mourani, Peter M.; Nadkarni, Vinay M.; Naim, Maryam Y.; and Notterman, Daniel, "Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial" (2023). GW Authored Works. Paper 3124.