Characteristics and Complications of Anogenital Infantile Hemangiomas: A Multicenter Retrospective Analysis
Journal of the American Academy of Dermatology
LUMBAR syndrome; congenital anomalies; genital development; infantile hemangiomas; ulceration; vascular anomalies
IMPORTANCE: Infantile hemangiomas (IHs) of the anogenital region remain poorly characterized. OBJECTIVE: To examine the distribution, ulceration rate, and associated congenital anomalies of anogenital IHs. METHODS: Retrospective study at 8 tertiary referral centers. RESULTS: A total of 435 infants with an IH of the anogenital region were enrolled (319 female, [73%]). Congenital anomalies were present in 6.4% (n=28) of infants with an anogenital IH. Segmental/partial segmental anogenital IHs ulcerated in 72% (n=99 of 138) of infants, while 45% (n=133 of 297) of focal anogenital IHs experienced ulceration (P= <.001). In a multivariable logistic regression analysis, segmental/partial segmental morphology (adjusted odds ratio [aOR] 2.70, 95% confidence interval [CI] 1.60-4.64), mixed type (aOR 3.44, 95% CI 2.01-6.07), perianal (aOR 3.01, 95% CI 1.53-6.12) and buttocks location (aOR 2.08, 95% CI 1.17-3.76), had an increased odds of ulceration. Segmental/partial segmental IHs of the genitalia were confined to distinct anatomic territories and were predominantly distributed unilaterally with a linear demarcation at the perineal raphe. LIMITATIONS: Possible selection bias given recruitment at tertiary referral centers. CONCLUSIONS AND RELEVANCE: This study improves our understanding of high-risk features of anogenital IHs and demonstrates that genital segmental/partial segmental IHs develop within distinct anatomic territories.
Arnold, Justin D.; Yoon, SunJung; Shah, Nidhi; Byrne, Morgan; Kieswetter, Lukas; Sibbald, Cathryn; Lara-Corrales, Irene; Kinariwalla, Neha; Garzon, Maria C.; Braun, Mitchell; Shah, Sonal D.; Frieden, Ilona J.; Travis, Nicole; Liy Wong, Carmen; Snyder, Alan N.; Wine Lee, Lara; Collier, Erin K.; Hogeling, Marcia; Fernandez Faith, Esteban; DeVaul, Nicole; and Kirkorian, A Yasmine, "Characteristics and Complications of Anogenital Infantile Hemangiomas: A Multicenter Retrospective Analysis" (2023). GW Authored Works. Paper 3088.