Neonatal brain MRI and short-term outcomes after acute provoked seizures
Journal of perinatology : official journal of the California Perinatal Association
OBJECTIVE: We investigated how diagnosis and injury location on neonatal brain MRI following onset of acute provoked seizures was associated with short term outcome. STUDY DESIGN: A multicenter cohort of neonates with acute provoked seizures enrolled in the Neonatal Seizure Registry. MRIs were centrally evaluated by a neuroradiologist for location of injury and radiologic diagnosis. Clinical outcomes were determined by chart review. Multivariate logistic regression was used to examine the association between MRI findings and outcomes. RESULTS: Among 236 newborns with MRI at median age 4 days (IQR 3-8), 91% had abnormal MRI. Radiologic diagnoses of intracranial hemorrhage (OR 3.2 [1.6-6.5], p < 0.001) and hypoxic-ischemic encephalopathy (OR 2.7 [1.4-5.4], p < 0.003) were associated with high seizure burden. Radiologic signs of intracranial infection were associated with abnormal neurologic examination at discharge (OR 3.9 [1.3-11.6], p < 0.01). CONCLUSION: Findings on initial MRI can help with expectant counseling on short-term outcomes following acute provoked neonatal seizures.
Li, Yi; Scheffler, Aaron; Barkovich, Anthony James; Chang, Taeun; Chu, Catherine J.; Massey, Shavonne L.; Abend, Nicholas S.; Lemmon, Monica E.; Thomas, Cameron; Numis, Adam; Franck, Linda S.; Rogers, Elizabeth; Callen, Andrew; McCulloch, Charles E.; Shellhaas, Renée A.; and Glass, Hannah C., "Neonatal brain MRI and short-term outcomes after acute provoked seizures" (2023). GW Authored Works. Paper 3070.