Neonatal brain MRI and short-term outcomes after acute provoked seizures

Authors

• Yi Li, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. yi.li@ucsf.edu.
• Aaron Scheffler, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
• Anthony James Barkovich, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
• Taeun Chang, Department of Neurology, Children's National Hospital, George Washington University School of Medicine, Washington, DC, USA.
• Catherine J. Chu, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
• Shavonne L. Massey, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
• Nicholas S. Abend, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
• Monica E. Lemmon, Department of Pediatrics and Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
• Cameron Thomas, Department of Pediatrics, University of Cincinnati and Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
• Adam Numis, Department of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.
• Linda S. Franck, Department of Family Health Care Nursing, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.
• Elizabeth Rogers, Department of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.
• Andrew Callen, Department of Radiology, University of Colorado Denver School of Medicine, Denver, CO, USA.
• Charles E. McCulloch, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
• Renée A. Shellhaas, Division of Pediatric Neurology, Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
• Hannah C. Glass, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Document Type

Journal Article

Publication Date

7-15-2023

Journal

Journal of perinatology : official journal of the California Perinatal Association

DOI

10.1038/s41372-023-01723-3

Abstract

OBJECTIVE: We investigated how diagnosis and injury location on neonatal brain MRI following onset of acute provoked seizures was associated with short term outcome. STUDY DESIGN: A multicenter cohort of neonates with acute provoked seizures enrolled in the Neonatal Seizure Registry. MRIs were centrally evaluated by a neuroradiologist for location of injury and radiologic diagnosis. Clinical outcomes were determined by chart review. Multivariate logistic regression was used to examine the association between MRI findings and outcomes. RESULTS: Among 236 newborns with MRI at median age 4 days (IQR 3-8), 91% had abnormal MRI. Radiologic diagnoses of intracranial hemorrhage (OR 3.2 [1.6-6.5], p < 0.001) and hypoxic-ischemic encephalopathy (OR 2.7 [1.4-5.4], p < 0.003) were associated with high seizure burden. Radiologic signs of intracranial infection were associated with abnormal neurologic examination at discharge (OR 3.9 [1.3-11.6], p < 0.01). CONCLUSION: Findings on initial MRI can help with expectant counseling on short-term outcomes following acute provoked neonatal seizures.

APA Citation

Li, Yi; Scheffler, Aaron; Barkovich, Anthony James; Chang, Taeun; Chu, Catherine J.; Massey, Shavonne L.; Abend, Nicholas S.; Lemmon, Monica E.; Thomas, Cameron; Numis, Adam; Franck, Linda S.; Rogers, Elizabeth; Callen, Andrew; McCulloch, Charles E.; Shellhaas, Renée A.; and Glass, Hannah C., "Neonatal brain MRI and short-term outcomes after acute provoked seizures" (2023). GW Authored Works. Paper 3070.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3070

Department

Neurology