The CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents - Study Rationale and Protocol

Christopher C. Giza, University of California Los Angeles David Geffen School of Medicine, 12222, Neurosurgery, Los Angeles, California, United States.
Gerry Gioia, Children's National Hospital, 8404, Neuropsychology, Washington, District of Columbia, United States.
Lawrence J. Cook, University of Utah Health, 14434, Pediatric Critical Care, Salt Lake City, Utah, United States; larry.cook@hsc.utah.edu.
Robert F. Asarnow, University of California Los Angeles David Geffen School of Medicine, 12222, Psychiatry and Biobehavioral Sciences, Los Angeles, California, United States.
Aliyah Snyder, University of Florida Health, 440202, Clinical And Health Psychology - Fixel Institute, Gainesville, Florida, United States.
Talin Babikian, University of California Los Angeles David Geffen School of Medicine, 12222, Psychiatry and Biobehavioral Sciences, Los Angeles, California, United States.
Paul Thompson, University of Southern California, 5116, Ophthalmology, Los Angeles, California, United States.
Jeffrey Bazarian, University of Rochester School of Medicine and Dentistry Official Bookstore, 397510, Emergency Medicine, 265 Crittenden Blvd, Box 655c, Rochester, New York, United States, 14642; jeff_bazarian@urmc.rochester.edu.
Christopher T. Whitlow, Wake Forest University School of Medicine, 12279, Radiology, Winston-Salem, North Carolina, United States.
Christopher M. Miles, Wake Forest University School of Medicine, 12279, Family and Community Medicine, Winston-Salem, North Carolina, United States.
Scott Otallah, Wake Forest University School of Medicine, 12279, Neurology, Winston-Salem, North Carolina, United States.
Joshua Kamins, University of California Los Angeles David Geffen School of Medicine, 12222, Neurology, Los Angeles, California, United States.
Nyaz Didehbani, The University of Texas Southwestern Medical Center, 12334, Psychiatry, Dallas, Texas, United States.
Philip Rosenbaum, University of California Los Angeles David Geffen School of Medicine, 12222, Neurosurgery, Los Angeles, California, United States.
Sara Pd Chrisman, Seattle Children's Research Institute, 145793, Center for Child Health, Behavior and Development, 1920 Terry Avenue, Seattle, Washington, United States, 98145-5005.
Christopher Vaughan, Children's National Health System, 8404, Neuropsychology, Washington, District of Columbia, United States; cvaughan@childrensnational.org.
C Munro Cullum, The University of Texas Southwestern Medical Center, 12334, Neurology and Neurotherapeutics, Dallas, Texas, United States.
David M. Popoli, Wake Forest University School of Medicine, 12279, Orthopaedics and Rehabilitation, Winston-Salem, North Carolina, United States.
Meeryo Choe, University of California Los Angeles David Geffen School of Medicine, 12222, Pediatric Neurology, Los Angeles, California, United States.
Jessica Gill, Johns Hopkins University School of Nursing, 15851, 525 north wolfe, Baltimore, Maryland, United States, 20892; jessicagill@jhu.edu.
Emily L. Dennis, The University of Utah School of Medicine, 12348, Neurology, Salt Lake City, Utah, United States; Emily.Dennis@hsc.utah.edu.
Christine L. Mac Donald, University of Washington School of Medicine, 12353, Neurological Surgery, Seattle, Washington, United States; cmacd@neurosurgery.washington.edu.
Frederick P. Rivara, Seattle Children's Research Institute, 145793, Center for Child Health, Behavior and Development, Seattle, Washington, United States; fpr@uw.edu.

Document Type

Journal Article

Publication Date

7-18-2023

Journal

Journal of neurotrauma

DOI

10.1089/neu.2023.0073

Keywords

BIOMARKERS; COGNITIVE FUNCTION; MRI; PEDIATRIC BRAIN INJURY; RECOVERY

Abstract

Treatment of youth concussion during the acute phase continues to evolve, and this has led to the emergence of guidelines to direct care. While symptoms after concussion typically resolve in 14-28 days, a portion (~20%) of adolescents endorse persistent post-concussive symptoms (PPCS) beyond normal resolution. This report outlines a study implemented in response to the National Institute of Neurological Diseases and Stroke call for the development and initial clinical validation of objective biological measures to predict risk of PPCS in adolescents. We describe our plans for recruitment of a Development cohort of 11-17-year-old youth with concussion, and collection of autonomic, neurocognitive, biofluid, and imaging biomarkers. The most promising of these measures will then be validated in a separate Validation cohort of youth with concussion and a final, clinically useful algorithm will be developed and disseminated. Upon completion of this study, we will have generated a battery of measures predictive of high risk for PPCS, which will allow for identification and testing of interventions to prevent PPCS in the most high-risk youth.

Department

Psychiatry and Behavioral Sciences

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