Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series

Authors

Shane D. Smith, Department of Pathology, The George Washington University, Washington, DC.
Navitha Woddor, Department of Pathology, The George Washington University, Washington, DC.
David S. Cassarino, Department of Pathology, Southern California Permanente Medical Group, Los Angeles, CA.
Wen Chen, Department of Pathology, The George Washington University, Washington, DC.
Nashay Clemetson, Department of Medicine, Dermatology, Veterans Affairs Medical Center, West Palm Beach, FL.
Victor E. Nava, Department of Pathology, The George Washington University, Washington, DC.

Document Type

Journal Article

Publication Date

6-1-2023

Journal

The American Journal of dermatopathology

Volume

45

Issue

6

DOI

10.1097/DAD.0000000000002428

Abstract

Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that disproportionately affects patients with skin of color. Genetic studies have revealed that approximately 30% of CCCAs are associated with peptidyl arginine deiminase 3 misfolding mutations. Patients with CCCA usually have a poor prognosis with progressive and permanent hair loss. To further characterize CCCA, we evaluated the inflammatory milieu, PDL1, and caspase 3 expression. The data support the idea of CCCA being a CD4-predominant T-cell process. The loss of PDL1 and increase in caspase 3 expression raises the possibility of involvement of the PD1/PDL1 pathway in CCCA.

APA Citation

Smith, Shane D.; Woddor, Navitha; Cassarino, David S.; Chen, Wen; Clemetson, Nashay; and Nava, Victor E., "Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series" (2023). GW Authored Works. Paper 2822.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2822

Department

Pathology