Androgen receptor amplification in mesonephric remnants
Document Type
Journal Article
Publication Date
6-9-2023
Journal
BMJ case reports
Volume
16
Issue
6
DOI
10.1136/bcr-2022-251741
Keywords
Obstetrics and gynaecology; Pathology
Abstract
Mesonephric remnants (MRs) are embryonic vestiges most commonly found in female pathology specimens from the lateral wall of the cervix. The highly regulated genetic programme of mesonephric duct development has been well characterised in animals based on traditional surgical castration and knockout mouse experiments. However, the process is incompletely understood in humans. MRs are believed to give rise to mesonephric neoplasms, which are rare tumours with uncertain pathophysiology. There is a dearth of molecular studies on mesonephric neoplasms in part due to their rarity. Here, we report the results of next-generation sequencing of MR, which identified amplification of the androgen receptor gene for the first time to the best of our knowledge and discuss the potential implications in the context of the literature.
APA Citation
Siddiqui, Gulnaz; Zara Rozalen, Alexandra; and Nava, Victor E., "Androgen receptor amplification in mesonephric remnants" (2023). GW Authored Works. Paper 2738.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2738
Department
Pathology