Sorting nexins: role in the regulation of blood pressure

Authors

Juan Huang, Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Andrew C. Tiu, Department of Medicine, Einstein Medical Center Philadelphia, PA, USA.
Pedro A. Jose, Division of Renal Diseases & Hypertension, Department of Medicine, The George Washington University School of Medicine & Health Sciences, DC, USA.
Jian Yang, Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Document Type

Journal Article

Publication Date

2-1-2023

Journal

The FEBS journal

Volume

290

Issue

3

DOI

10.1111/febs.16305

Keywords

antihypertensive treatment; blood pressure; hypertension; sorting nexin; trafficking

Abstract

Sorting nexins (SNXs) are a family of proteins that regulate cellular cargo sorting and trafficking, maintain intracellular protein homeostasis, and participate in intracellular signaling. SNXs are also important in the regulation of blood pressure via several mechanisms. Aberrant expression and dysfunction of SNXs participate in the dysregulation of blood pressure. Genetic studies show a correlation between SNX gene variants and the response to antihypertensive drugs. In this review, we summarize the progress in SNX-mediated regulation of blood pressure, discuss the potential role of SNXs in the pathophysiology and treatment of hypertension, and propose novel strategies for the medical therapy of hypertension.

APA Citation

Huang, Juan; Tiu, Andrew C.; Jose, Pedro A.; and Yang, Jian, "Sorting nexins: role in the regulation of blood pressure" (2023). GW Authored Works. Paper 2504.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2504

Department

Medicine