Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials

Authors

Sophie Thomas, Department of Paediatric Neuropsychology, Nottingham Children's Hospital, Queen's Medical Centre, Nottingham, UK.
Leanne Embry, Pediatric Hematology/Oncology, UT Health, San Antonio, Texas, USA.
Karin Walsh, Division of Pediatric Neuropsychology, Children's National Hospital, Washington, DC, USA.
Kim Bull, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, UK.
Richard Grundy, Department of Paediatric Neuropsychology, Nottingham Children's Hospital, Queen's Medical Centre, Nottingham, UK.
Colin Kennedy, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, UK.
Jurgen Lemiere, Department Oncology, Pediatric Hemato-Oncology, KULeuven, University Hospital Leuven, Leuven, Belgium.
Pablo Hernáiz Driever, Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Jennifer Limond, Department of Psychology, University of Exeter, Exeter, UK.
Mathilde Chevignard, Rehabilitation Department for Children with Acquired Neurological Injury; and Outreach Team for Children and Adolescents with Acquired Brain Injury, Saint Maurice Hospitals, Saint Maurice, France.
Kristina Hardy, Division of Pediatric Neuropsychology, Children's National Hospital, Washington, DC, USA.

Document Type

Journal Article

Publication Date

2-3-2023

Journal

Pediatric blood & cancer

DOI

10.1002/pbc.30171

Keywords

brain tumour; cancer; child; cognitive; late effects; paediatric; quality of survival

Abstract

The importance of measuring quality of survival within paediatric oncology trials is increasingly recognised. However, capturing neuropsychological outcomes and other aspects of quality of survival in the context of large or multinational trials can be challenging. We provide examples of protocols designed to address this challenge recently employed in clinical trials in the USA and Europe. We discuss their respective strengths and challenges, obstacles encountered and future opportunities for transatlantic collaboration.

APA Citation

Thomas, Sophie; Embry, Leanne; Walsh, Karin; Bull, Kim; Grundy, Richard; Kennedy, Colin; Lemiere, Jurgen; Hernáiz Driever, Pablo; Limond, Jennifer; Chevignard, Mathilde; and Hardy, Kristina, "Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials" (2023). GW Authored Works. Paper 2443.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2443

Department

Psychiatry and Behavioral Sciences