Proteomic Mediators of Overall Cardiovascular Health on All-Cause Mortality

Authors

Toshiko Tanaka, Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Sameera A. Talegawkar, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Yichen Jin, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Julián Candia, Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Giovanna Fantoni, Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Stefania Bandinelli, Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50137 Florence, Italy.
Luigi Ferrucci, Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.

Document Type

Journal Article

Publication Date

2-3-2023

Journal

Nutrients

Volume

15

Issue

3

DOI

10.3390/nu15030781

Keywords

all-cause mortality; cardiovascular health; mediation; proteomics

Abstract

Measures of cardiovascular health (CVH) assessed by a combination of behavioral and biological factors has shown protective associations with all-cause mortality. The mechanisms underlying these associations have not been fully elucidated. In this study, we characterized the plasma proteomics profile of CVH and tested whether specific proteins mediated the associations between CVH and all-cause mortality in participants of the InCHIANTI study. Of the 1301 proteins tested, 92 proteins were associated with CVH (22 positively, 70 negatively). Proteins most strongly associated with CVH included leptin (LEP), fatty acid binding protein 3 (FABP3), Angiopoietin-2 (ANGPT2), and growth-differential factor 15 (GDF15). Of the 92 CVH-associated proteins, 33 proteins significantly mediated the associations between CVH and all-cause mortality, with percent mediation ranging from 5 to 30%. The most significant mediating proteins were GDF15 and insulin-like growth factor 2 (IGFBP2). Proteins associated with better CVH were enriched for proteins that reflect the suppression of the complement coagulation and GH/IGF pathways.

APA Citation

Tanaka, Toshiko; Talegawkar, Sameera A.; Jin, Yichen; Candia, Julián; Fantoni, Giovanna; Bandinelli, Stefania; and Ferrucci, Luigi, "Proteomic Mediators of Overall Cardiovascular Health on All-Cause Mortality" (2023). GW Authored Works. Paper 2441.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2441

Department

Exercise and Nutrition Sciences