Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis

Document Type

Journal Article

Publication Date

2-20-2023

Journal

Chemical research in toxicology

Volume

36

Issue

2

DOI

10.1021/acs.chemrestox.2c00412

Abstract

Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without reduced nicotine levels. Amounts of furan mercapturic acid metabolites were higher in these individuals relative to nonsmokers, indicating that they may be at risk for potential furan-derived toxicities.

Department

Exercise and Nutrition Sciences

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