Accelerating the development of vaccine microarray patches for epidemic response and equitable immunization coverage requires investment in microarray patch manufacturing facilities

Document Type

Journal Article

Publication Date

1-27-2023

Journal

Expert opinion on drug delivery

DOI

10.1080/17425247.2023.2168641

Keywords

De-risking strategies; Microarray patches; coverage and equity; microneedle patches; pandemic preparedness; pilot manufacturing facilities; product development; vaccine delivery; vaccine development incentives; vaccine manufacturing

Abstract

INTRODUCTION: There is a need for investment in manufacturing for vaccine microarray patches (vMAPs) to accelerate vMAP development and access. vMAPs could transform vaccines deployment and reach to everyone, everywhere. AREAS COVERED: We outline vMAPs' potential benefits for epidemic preparedness and for outreach in low- and lower-middle-income countries (LMICs), share lessons learned from pandemic response, and highlight that investment in manufacturing-at-risk could accelerate vMAP development. EXPERT OPINION: Pilot manufacturing capabilities are needed to produce clinical trial material and enable emergency response. Funding vMAP manufacturing scale-up in parallel to clinical proof-of-concept studies could accelerate vMAP approval and availability. Incentives could mitigate the risks of establishing multi-vMAP manufacturing facilities early.

Department

Emergency Medicine

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