Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis

Authors

Karin R. Vevang, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Lin Zhang, Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Alex E. Grill, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Dorothy K. Hatsukami, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Ellen Meier, Department of Psychology, University of Wisconsin-Stevens Point, Stevens Point, Wisconsin 54481, United States.
Sarah Oppeneer Nomura, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Kim Robien, Department of Exercise and Nutrition Sciences, George Washington University, Washington, DC 20052, United States.
Lisa A. Peterson, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Document Type

Journal Article

Publication Date

1-30-2023

Journal

Chemical research in toxicology

DOI

10.1021/acs.chemrestox.2c00412

Abstract

Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without reduced nicotine levels. Amounts of furan mercapturic acid metabolites were higher in these individuals relative to nonsmokers, indicating that they may be at risk for potential furan-derived toxicities.

APA Citation

Vevang, Karin R.; Zhang, Lin; Grill, Alex E.; Hatsukami, Dorothy K.; Meier, Ellen; Nomura, Sarah Oppeneer; Robien, Kim; and Peterson, Lisa A., "Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis" (2023). GW Authored Works. Paper 2219.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2219

Department

Exercise and Nutrition Sciences