Advances in the clinical management of high-risk Wilms tumors
Document Type
Journal Article
Publication Date
3-1-2023
Journal
Pediatric blood & cancer
Volume
70
Issue
3
DOI
10.1002/pbc.30153
Keywords
COG; SIOP; Wilms tumor; high risk; nephroblastoma; relapsed
Abstract
Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50% or lower. Acknowledging that the composition of this high-risk group has changed over time reflecting improvements in therapy, we introduce the authors' view of the historical and current approach to the classification and treatment of high-risk WT. For this review, we consider high-risk WT to include patients with newly diagnosed metastatic blastemal-type or diffuse anaplastic histology, those who relapse after having been initially treated with three or more different chemotherapeutics, or those who relapse more than once. In certain low- or low middle-income settings, socio-economic factors expand the definition of what constitutes a high-risk WT. As conventional therapies are inadequate to cure the majority of high-risk WT patients, advancement of laboratory and early-phase clinical investigations to identify active agents is urgently needed.
APA Citation
Ortiz, Michael V.; Koenig, Christa; Armstrong, Amy E.; Brok, Jesper; de Camargo, Beatriz; Mavinkurve-Groothuis, Annelies M.; Herrera, Thelma B.; Venkatramani, Rajkumar; Woods, Andrew D.; Dome, Jeffrey S.; and Spreafico, Filippo, "Advances in the clinical management of high-risk Wilms tumors" (2023). GW Authored Works. Paper 2212.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2212
Department
Pediatrics