Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Lack of a gold standard can present a challenge for evaluation of diagnostic test accuracy of some infectious diseases tests, particularly when the test's accuracy potentially exceeds that of its predecessors. This approach may measure agreement with an imperfect reference, rather than correctness, since the right answer is unknown. Solutions consist of multi-test comparators, including those that involve a test under evaluation if multiple new tests are being evaluated together, latent class modeling, and clinically adjudicated reference standards. Clinically adjudicated reference standards may be considered as comparator methods when no pre-defined test or composite of tests is sufficiently accurate; they emulate clinical practice in that multiple data pieces are clinically assessed together.
Patel, Robin; Tsalik, Ephraim L.; Evans, Scott; Fowler, Vance G.; and Doernberg, Sarah B., "Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics" (2022). GW Authored Works. Paper 1752.
Biostatistics and Bioinformatics