Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

Authors

Jokubas Ausra, Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA.
Micah Madrid, Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
Rose T. Yin, Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
Jessica Hanna, Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA.
Suzanne Arnott, Department of Surgery, The George Washington University, Washington, DC 20037, USA.
Jaclyn A. Brennan, Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
Roberto Peralta, Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721, USA.
David Clausen, Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA.
Jakob A. Bakall, Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA.
Igor R. Efimov, Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
Philipp Gutruf, Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA.

Document Type

Journal Article

Publication Date

10-28-2022

Journal

Science advances

Volume

8

Issue

43

DOI

10.1126/sciadv.abq7469

Abstract

Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning-guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject.

APA Citation

Ausra, Jokubas; Madrid, Micah; Yin, Rose T.; Hanna, Jessica; Arnott, Suzanne; Brennan, Jaclyn A.; Peralta, Roberto; Clausen, David; Bakall, Jakob A.; Efimov, Igor R.; and Gutruf, Philipp, "Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation" (2022). GW Authored Works. Paper 1726.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/1726

Department

School of Medicine and Health Sciences Resident Works