Clinical H MRS in childhood neurometabolic diseases-part 1: technique and age-related normal spectra

Authors

Matthew T. Whitehead, Department of Neuroradiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC, 20010, USA. MWhitehe@childrensnational.org.
Lillian M. Lai, Department of Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Stefan Blüml, Department of Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, USA.

Document Type

Journal Article

Publication Date

2-18-2022

Journal

Neuroradiology

DOI

10.1007/s00234-022-02917-w

Keywords

MRS; Metabolic; Metabolism; Spectroscopy

Abstract

Despite its vigorous ability to detect and measure metabolic disturbances, H MRS remains underutilized in clinical practice. MRS increases diagnostic yield and provides therapeutic measures. Because many inborn metabolic errors are now treatable, early diagnosis is crucial to prevent or curb permanent brain injury. Therefore, patients with known or suspected inborn metabolic errors stand to benefit from the addition of MRS. With education and practice, all neuroradiologists can perform and interpret MRS notwithstanding their training and prior experience. In this two-part review, we cover the requisite concepts for clinical MRS interpretation including technical considerations and normal brain spectral patterns based on age, location, and methodology.

APA Citation

Whitehead, Matthew T.; Lai, Lillian M.; and Blüml, Stefan, "Clinical H MRS in childhood neurometabolic diseases-part 1: technique and age-related normal spectra" (2022). GW Authored Works. Paper 141.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/141

Department

Pediatrics