Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy

Authors

Brita Ostermeier, Department of Microbiology Immunology and Tropical Medicine, The George Washington University, 2300 I Street NW, Washington, DC 20037, USA.
Natalia Soriano-Sarabia, Department of Microbiology Immunology and Tropical Medicine, The George Washington University, 2300 I Street NW, Washington, DC 20037, USA.
Sanjay B. Maggirwar, Department of Microbiology Immunology and Tropical Medicine, The George Washington University, 2300 I Street NW, Washington, DC 20037, USA.

Document Type

Journal Article

Publication Date

2-19-2022

Journal

International journal of molecular sciences

Volume

23

Issue

4

DOI

10.3390/ijms23042321

Keywords

microparticles; microvesicle; platelets; therapy; vesicles; virus

Abstract

Platelets, which are small anuclear cell fragments, play important roles in thrombosis and hemostasis, but also actively release factors that can both suppress and induce viral infections. Platelet-released factors include sCD40L, microvesicles (MVs), and alpha granules that have the capacity to exert either pro-inflammatory or anti-inflammatory effects depending on the virus. These factors are prime targets for use in extracellular vesicle (EV)-based therapy due to their ability to reduce viral infections and exert anti-inflammatory effects. While there are some studies regarding platelet microvesicle-based (PMV-based) therapy, there is still much to learn about PMVs before such therapy can be used. This review provides the background necessary to understand the roles of platelet-released factors, how these factors might be useful in PMV-based therapy, and a critical discussion of current knowledge of platelets and their role in viral diseases.

APA Citation

Ostermeier, Brita; Soriano-Sarabia, Natalia; and Maggirwar, Sanjay B., "Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy" (2022). GW Authored Works. Paper 135.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/135

Department

Microbiology, Immunology, and Tropical Medicine