Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity

Authors

Nemanja Sarić, Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA.
Kazue Hashimoto-Torii, Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA; Department of Pediatrics, Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Vesna Jevtović-Todorović, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
Nobuyuki Ishibashi, Center for Neuroscience Research, Children's National Hospital, Washington, DC, USA; Department of Pediatrics, Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Children's National Heart Institute, Children's National Hospital, Washington, DC, USA. Electronic address: nishibas@childrensnational.org.

Document Type

Journal Article

Publication Date

6-1-2022

Journal

Trends in neurosciences

Volume

45

Issue

6

DOI

10.1016/j.tins.2022.03.007

Keywords

anesthesia; neurodegeneration; neurodevelopment; nonlethal caspase

Abstract

Apoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain maturation and long-term effects on behavior. In this review, we discuss key molecular characteristics and roles of the noncanonical caspase pathway and how its dysregulation may adversely affect brain development. We highlight both genetic and environmental factors that regulate apoptotic and sublethal caspase responses and discuss potential interventions that target the noncanonical caspase pathway for developmental brain injuries.

APA Citation

Sarić, Nemanja; Hashimoto-Torii, Kazue; Jevtović-Todorović, Vesna; and Ishibashi, Nobuyuki, "Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity" (2022). GW Authored Works. Paper 1238.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/1238

Department

Pediatrics