Impact of oxidative stress on risk of death and readmission in African children with severe malaria: a prospective observational study

Daniel B. Blatt, Department of Pediatrics, Division of Infectious Diseases, University of Louisville, Louisville, KY, United States.
Benjamin Hanisch, Department of Pediatrics, Division of Infectious Diseases, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Katrina Co, Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, United States.
Dibyadyuti Datta, Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, United States.
Caitlin Bond, Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, United States.
Robert O. Opoka, Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, United States.
Sarah E. Cusick, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Ian C. Michelow, Department of Pediatrics, Division of Infectious Diseases, Connecticut Children's Medical Center, University of Connecticut School of Medicine, United States.
Chandy C. John, Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, United States.

Document Type

Journal Article

Publication Date

6-9-2022

Journal

The Journal of infectious diseases

DOI

10.1093/infdis/jiac234

Keywords

Plasmodium falciparum; cerebral malaria; child; heme oxygenase-1; malaria; malondialdehyd; oxidative stress; severe malarial anemia; superoxide dismutase

Abstract

BACKGROUND: We hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality. METHODS: We evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n = 77) or severe malarial anemia (SMA, n = 79), who were enrolled in a randomized clinical trial of immediate vs. delayed iron therapy, compared with community children (CC, n = 83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed. RESULTS: Nine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1, p < 0.001) and lower superoxide dismutase (SOD) activity than CC (p < 0.02). Children with CM had a higher risk of death with increasing HO-1 concentration (odds ratio (OR) [95% confidence interval, (CI)], 6.07 [1.17-31.31], p = 0.03), but a lower risk of death with increasing SOD activity (OR [95% CI], 0.02 [0.001-0.70], p = 0.03). There were no associations between oxidative stress biomarkers on admission and risk of readmission within 6 months of enrolment. CONCLUSIONS: Children with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA. Registered at clinicaltrials.gov as NCT01093989.

Department

Pediatrics

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