Milken Institute School of Public Health Poster Presentations (Marvin Center & Video)

Prolonged Low-Calorie Sweetener Consumption Disturbs Inflammatory Pathways in Adipose Tissue among Overweight and Obese Young Adults

Document Type

Poster

Abstract Category

Exercise and Nutrition Sciences

Keywords

LCS, Inflammation, Immune, Adipocytes, IL-6

Publication Date

Spring 5-1-2019

Abstract

With consistent high rates of consumption of low-calorie sweeteners (LCS) among the US adult population, further research is needed to better understand the metabolic effects of prolonged LCS consumption. By studying a healthy population under controlled conditions, we found LCS exposure to affect 1117 genes, the majority of which were involved in immune and inflammatory pathways. A trend toward increasing circulating levels of IL-6 was also observed (p=0.05). These data will serve as the basis for testing clinically relevant metabolic effects of prolonged LCS exposure in a randomized trial with a larger cohort and longer duration.

Open Access

1

Comments

Presented at Research Days 2019.

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Prolonged Low-Calorie Sweetener Consumption Disturbs Inflammatory Pathways in Adipose Tissue among Overweight and Obese Young Adults

With consistent high rates of consumption of low-calorie sweeteners (LCS) among the US adult population, further research is needed to better understand the metabolic effects of prolonged LCS consumption. By studying a healthy population under controlled conditions, we found LCS exposure to affect 1117 genes, the majority of which were involved in immune and inflammatory pathways. A trend toward increasing circulating levels of IL-6 was also observed (p=0.05). These data will serve as the basis for testing clinically relevant metabolic effects of prolonged LCS exposure in a randomized trial with a larger cohort and longer duration.