School of Medicine and Health Sciences Poster Presentations
Evaluation of Family’s Willingness to Pay and Cost Effectiveness for Fertility Sparing Technology in Prepubescent Males Undergoing Gonadotoxic Chemotherapy
Poster Number
184
Document Type
Poster
Publication Date
3-2016
Abstract
Introduction: We are performing a cost-effectiveness analysis to determine the optimal experimental fertility preservation method to achieve fertility in prepubescent males who have undergone gonadotoxic chemotherapy. Each year in the United States, approximately 12,400 children and adolescents younger than 20 years old are diagnosed with cancer. The use of chemotherapy in treatment of these cancers often results in sterility. Cryopreservation of gonadal tissue in prepubescent males for use later in life via assisted reproductive technology is currently an investigational procedure, however the only possible option for this patient population. Although investigational, current techniques show great promise to be of clinical utility in the near future. In this study, we perform a cost-effective analysis to determine how efficacious cryopreservation followed by restored fertility and in vitro fertilization must be for families to find the cost acceptable.
Methods: Decision Analysis (DA) is a quantitative approach that allows an investigator to break down a problem into a series of choices and outcomes. The results of such analysis have broad applications from individual treatment decisions to development of policies regarding groups of similar patients. In this study, an extension of DA called cost-effectiveness analysis is used which takes into account cost as a variable in choosing a treatment option.
We are currently using literature, institutional practice, and expert opinion to determine outcomes and costs of experimental fertility preservation protocols combined with intracytoplasmic sperm injection (ICSI). We will use these variables to fill in a decision tree incorporating various fertility sparing treatments: pluripotent stem cell culture (iPSC), xenotransplant, autotransplant, organ culture, and spermatogonial stem cell culture. All of these methods require ICSI to result in successful fertilization. We are modeling a cost-effectiveness analysis from the perspective of the patient.
Results: Our goal is to determine the most cost-effective method of restoring fertility in cryopreserved tissue in order to aid future families in selecting a treatment method, as well as help direct the focus of developing these technologies. The results of our study will also dictate how efficacious restored fertility in prepubescent males must be in order for families to find the costs acceptable.
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Open Access
1
Evaluation of Family’s Willingness to Pay and Cost Effectiveness for Fertility Sparing Technology in Prepubescent Males Undergoing Gonadotoxic Chemotherapy
Introduction: We are performing a cost-effectiveness analysis to determine the optimal experimental fertility preservation method to achieve fertility in prepubescent males who have undergone gonadotoxic chemotherapy. Each year in the United States, approximately 12,400 children and adolescents younger than 20 years old are diagnosed with cancer. The use of chemotherapy in treatment of these cancers often results in sterility. Cryopreservation of gonadal tissue in prepubescent males for use later in life via assisted reproductive technology is currently an investigational procedure, however the only possible option for this patient population. Although investigational, current techniques show great promise to be of clinical utility in the near future. In this study, we perform a cost-effective analysis to determine how efficacious cryopreservation followed by restored fertility and in vitro fertilization must be for families to find the cost acceptable.
Methods: Decision Analysis (DA) is a quantitative approach that allows an investigator to break down a problem into a series of choices and outcomes. The results of such analysis have broad applications from individual treatment decisions to development of policies regarding groups of similar patients. In this study, an extension of DA called cost-effectiveness analysis is used which takes into account cost as a variable in choosing a treatment option.
We are currently using literature, institutional practice, and expert opinion to determine outcomes and costs of experimental fertility preservation protocols combined with intracytoplasmic sperm injection (ICSI). We will use these variables to fill in a decision tree incorporating various fertility sparing treatments: pluripotent stem cell culture (iPSC), xenotransplant, autotransplant, organ culture, and spermatogonial stem cell culture. All of these methods require ICSI to result in successful fertilization. We are modeling a cost-effectiveness analysis from the perspective of the patient.
Results: Our goal is to determine the most cost-effective method of restoring fertility in cryopreserved tissue in order to aid future families in selecting a treatment method, as well as help direct the focus of developing these technologies. The results of our study will also dictate how efficacious restored fertility in prepubescent males must be in order for families to find the costs acceptable.
Comments
Presented at: GW Research Days 2016