Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.

Authors

Srinika Ranasinghe
Pedro A Lamothe
Damien Z Soghoian
Samuel W Kazer
Michael B Cole
Alex K Shalek
Nir Yosef
R. Brad JonesFollow
Faith Donaghey
Chioma Nwonu
Priya Jani
Gina M Clayton
Frances Crawford
Janice White
Alana Montoya
Karen Power
Todd M Allen
Hendrik Streeck
Daniel E Kaufmann
Louis J Picker
John W Kappler
Bruce D Walker

Document Type

Journal Article

Publication Date

10-18-2016

Journal

Immunity

Volume

45

Issue

4

Inclusive Pages

917-930

DOI

10.1016/j.immuni.2016.09.015

Abstract

CD8(+) T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8(+) T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8(+) T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8(+) T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8(+) T cell responses can exist in a chronic human viral infection, and may contribute to immune control.

Comments

Reproduced with permission of Elsevier B.V. Immunity

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

APA Citation

Ranasinghe, S., Lamothe, P., Soghoian, D., Kazer, S., Cole, M., Shalek, A., Yosef, N., Jones, R. B., Donaghey, F., Nwonu, C., Jani, P., Clayton, G., Crawford, F., White, J., Montoya, A., Power, K., Allen, T., Streeck, H., Kaufmann, D., Picker, L., Kappler, J., & Walker, B. (2016). Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.. Immunity, 45 (4). http://dx.doi.org/10.1016/j.immuni.2016.09.015

Peer Reviewed

1

Open Access

1