Document Type
Journal Article
Publication Date
3-1-2016
Journal
Data in Brief
Volume
6
Inclusive Pages
168-175
DOI
10.1016/j.dib.2015.11.067
Abstract
Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain" [1].
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Meikle, P., Low, H., Churchill, M. J., Bukrinsky, M., & Sviridov, D. (2016). Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain. Data in Brief, 6, 168–175. http://doi.org/10.1016/j.dib.2015.11.067
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of Elsevier B.V. Data Brief.