Journal of Clinical Medicine
As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8)
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Badal-Faesen, S., Firnhaber, C., Kendall, M., Wu, X., Grinsztejn, B., Escada, R., Fernandez, M., Hogg, E., Sanne, I., Johnson, P., Alland, D., Mazurek, G., Benator, D., & Luetkemeyer, A. (2017). Impact of Larger Sputum Volume on Xpert(®) MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis.. Journal of Clinical Medicine, 6 (8). http://dx.doi.org/10.3390/jcm6080078