Document Type

Journal Article

Publication Date

1-18-2013

Journal

Journal of Biological Chemistry

Volume

Volume 288, Issue 3

Inclusive Pages

1480-1488

Keywords

Autoantigens--genetics; Centromere--metabolism; Chromatin Assembly and Disassembly; Chromosomal Proteins; Non-Histone--genetics; Chromosomes; Human--metabolism; DNA-Binding Proteins--genetics

Abstract

Background: The incorporation of CENP-A at centromeres is important for chromosome segregation during mitosis.

Results: And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres.

Conclusion: And-1 facilitates the recruitment of CENP-A to centromeres.

Significance: These studies reveal a novel role of And-1 in the regulation of chromosome congression during mitosis.

Comments

This research was originally published in Journal of Biological Chemistry. Aimee Jaramillo-Lambert, Jing Hao, Haijie Xiao, Yongming Li, Zhiyong Han, and Wenge Zhu. Acidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres. Journal of Biological Chemistry. 2012; 288:1480-1488. © the American Society for Biochemistry and Molecular Biology.

Peer Reviewed

1

Open Access

1

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