Journal of Biological Chemistry
Volume 288, Issue 3
Autoantigens--genetics; Centromere--metabolism; Chromatin Assembly and Disassembly; Chromosomal Proteins; Non-Histone--genetics; Chromosomes; Human--metabolism; DNA-Binding Proteins--genetics
Background: The incorporation of CENP-A at centromeres is important for chromosome segregation during mitosis.
Results: And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres.
Conclusion: And-1 facilitates the recruitment of CENP-A to centromeres.
Significance: These studies reveal a novel role of And-1 in the regulation of chromosome congression during mitosis.
Jaramillo-Lambert, A., Hao, J., Xiao, H., Li, Y., Han, Z., & Zhu, W. (2013). Acidic nucleoplasmic DNA-binding protein (and-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres. Journal of Biological Chemistry, 288(3), 1480-1488.