Document Type
Journal Article
Publication Date
1-1-2016
Journal
PLoS One
Volume
11
Issue
7
Inclusive Pages
e0159958
DOI
10.1371/journal.pone.0159958
Abstract
Introduction
Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM.
Method
EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels’ density of -30 to -190 Hounsfield Unit. The associations were assessed using–Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting.
Results
The weighted mean age was 43 years (range 32–57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p
Conclusion
T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Darabian, S., Backlund, J., Cleary, P., Sheidaee, N., Bebu, I., Lachin, J. M., Budoff, M., & DCCT/EDIC Research Group (2016). Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study.. PLoS One, 11 (7). http://dx.doi.org/10.1371/journal.pone.0159958
Peer Reviewed
1
Open Access
1
Included in
Biostatistics Commons, Endocrinology, Diabetes, and Metabolism Commons, Epidemiology Commons
Comments
Reproduced with permission of PLoS ONE.