Infant Pneumococcal Carriage during Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial
Journal of Infectious Diseases
hMPV; influenza; maternal immunization; pneumococcus; RSV; vaccine
© 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection.
Murray, A., Englund, J., Kuypers, J., Tielsch, J., Katz, J., Khatry, S., Leclerq, S., & Chu, H. (2019). Infant Pneumococcal Carriage during Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial. Journal of Infectious Diseases, 220 (6). http://dx.doi.org/10.1093/infdis/jiz212