Title

Infant Pneumococcal Carriage during Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial

Document Type

Journal Article

Publication Date

8-9-2019

Journal

Journal of Infectious Diseases

Volume

220

Issue

6

DOI

10.1093/infdis/jiz212

Keywords

hMPV; influenza; maternal immunization; pneumococcus; RSV; vaccine

Abstract

© 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection.

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