Title

Influenza or Meningococcal Immunization during Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials

Document Type

Journal Article

Publication Date

1-1-2020

Journal

Pediatric Infectious Disease Journal

DOI

10.1097/INF.0000000000002629

Keywords

influenza; Maternal immunization; meningococcal; randomized controlled trial; vaccine

Abstract

© 2020 Lippincott Williams and Wilkins. All rights reserved. This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.

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