Influenza or Meningococcal Immunization during Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials
Pediatric Infectious Disease Journal
influenza; Maternal immunization; meningococcal; randomized controlled trial; vaccine
© 2020 Lippincott Williams and Wilkins. All rights reserved. This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.
Clark, D., Omer, S., Tapia, M., Nunes, M., Cutland, C., Tielsch, J., Wairagkar, N., & Madhi, S. (2020). Influenza or Meningococcal Immunization during Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials. Pediatric Infectious Disease Journal, (). http://dx.doi.org/10.1097/INF.0000000000002629