expression of members of the heat-shock protein 70 family in the exoerythrocytic stages of Plasmodium berghei and Plasmodium falciparum

Authors

Nirbhay Kumar, Johns Hopkins Bloomberg School of Public Health
Hideyuki Nagasawa, Case Western Reserve University
John B. Sacci, University of Maryland, Baltimore (UMB)
Barbara J. Sina, Biomedical Research Institute, Rockville
Masamichi Aikawa, Case Western Reserve University
C. Atkinson
Pichart Uparanukraw, Johns Hopkins Bloomberg School of Public Health
Laura B. Kubiak, University of Maryland, Baltimore (UMB)
Abdu F. Azad, University of Maryland, Baltimore (UMB)
Michael R. Hollingdale, Biomedical Research Institute, Rockville

Document Type

Journal Article

Publication Date

2-1-1993

Journal

Parasitology Research

Volume

79

Issue

2

DOI

10.1007/BF00932255

Abstract

Exoerythrocytic stages of Plasmodium berghei cultured in HepG2-A16 hepatoma cells and those of P. falciparum in human hepatocytes transplanted under the kidney capsule of CB-17/ICr scid/scid mice were used to evaluate expression of heat-shock-related stress proteins. Although undetectable in the sporozoites, the expression of proteins similar in sequence of a heat-shock protein of 70 kDa and a glucose-regulated protein of 78 kDa was markedly induced in the hepatic stages of malaria parasites. Expression of these proteins in the exoerythrocytic stages of the malaria parasite warrants a systematic evaluation of their potential role in eliciting cellular immune responses directed against infected hepatocytes. © 1993 Springer-Verlag.

APA Citation

Kumar, N., Nagasawa, H., Sacci, J., Sina, B., Aikawa, M., Atkinson, C., Uparanukraw, P., Kubiak, L., Azad, A., & Hollingdale, M. (1993). expression of members of the heat-shock protein 70 family in the exoerythrocytic stages of Plasmodium berghei and Plasmodium falciparum. Parasitology Research, 79 (2). http://dx.doi.org/10.1007/BF00932255