A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas
Growth inhibition assay; Plasmodium falciparum
Plasma samples from patients undergoing treatment in malaria endemic countries often contain anti-malaria drugs, that may overstate effects of specific antibodies in growth inhibition assays (GIA). We describe a modified assay that uses drug resistant P. falciparum parasites (W2) that circumvents the requirement for dialyzing samples that may likely contain drugs such as chloroquine and sulfadoxine/pyrimethamine (SP). © 2006 Elsevier Inc. All rights reserved.
Mlambo, G., & Kumar, N. (2007). A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas. Experimental Parasitology, 115 (2). http://dx.doi.org/10.1016/j.exppara.2006.08.003