Transdermal diagnosis of malaria using vapor nanobubbles

Authors

Ekaterina Lukianova-Hleb, Rice University
Sarah Bezek, Baylor College of Medicine
Reka Szigeti, Baylor College of Medicine
Alexander Khodarev, X Instruments LLC
Thomas Kelley, Precision Acoustics Ltd
Andrew Hurrell, Precision Acoustics Ltd
Michail Berba, Standa UAB
Nirbhay Kumar, Tulane University
Umberto D’Alessandro, Medical Research Council Laboratories Gambia
Dmitri Lapotko, Rice University

Document Type

Journal Article

Publication Date

1-1-2015

Journal

Emerging Infectious Diseases

Volume

21

Issue

7

DOI

10.3201/eid2107.150089

Abstract

© 2015, Centers for Disease Control and Prevention (CDC). All rights reserved. A fast, precise, noninvasive, high-throughput, and simple approach for detecting malaria in humans and mosquitoes is not possible with current techniques that depend on blood sampling, reagents, facilities, tedious procedures, and trained personnel. We designed a device for rapid (20-second) noninvasive diagnosis of Plasmodium falciparum infection in a malaria patient without drawing blood or using any reagent. This method uses transdermal optical excitation and acoustic detection of vapor nanobubbles around intraparasite hemozoin. The same device also identified individual malaria parasite–infected Anopheles mosquitoes in a few seconds and can be realized as a low-cost universal tool for clinical and field diagnoses.

APA Citation

Lukianova-Hleb, E., Bezek, S., Szigeti, R., Khodarev, A., Kelley, T., Hurrell, A., Berba, M., Kumar, N., D’Alessandro, U., & Lapotko, D. (2015). Transdermal diagnosis of malaria using vapor nanobubbles. Emerging Infectious Diseases, 21 (7). http://dx.doi.org/10.3201/eid2107.150089