Clinical Infectious Diseases
The Pneumonia Etiology Research for Child Health (PERCH) study is the largest multicountry etiology study of pediatric pneumonia undertaken in the past 3 decades. The study enrolled 4232 hospitalized cases and 5325 controls over 2 years across 9 research sites in 7 countries in Africa and Asia. The volume and complexity of data collection in PERCH presented considerable logistical and technical challenges. The project chose an internet-based data entry system to allow real-time access to the data, enabling the project to monitor and clean incoming data and perform preliminary analyses throughout the study. To ensure high-quality data, the project developed comprehensive quality indicator, data query, and monitoring reports. Among the approximately 9000 cases and controls, analyzable laboratory results were available for ≥96% of core specimens collected. Selected approaches to data management in PERCH may be extended to the planning and organization of international studies of similar scope and complexity.
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Watson, N., Prosperi, C., Driscoll, A., Higdon, M., Park, D., Sanza, M., DeLuca, A., Awori, J., Goswami, D., Hammond, E., Hossain, L., Johnson, C., Kamau, A., Kuwanda, L., Moore, D., Neyzari, O., Onwuchekwa, U., Parker, D., & Sapchookul, P. (2017). Data Management and Data Quality in PERCH, a Large International Case-Control Study of Severe Childhood Pneumonia.. Clinical Infectious Diseases, 64 (suppl. 3). http://dx.doi.org/10.1093/cid/cix080