Document Type
Journal Article
Publication Date
8-2015
Journal
American Journal of Industrial Medicine
Volume
58
Issue
8
Inclusive Pages
905-913
DOI
10.1002/ajim.22479
Keywords
Chromium--toxicity; Lung Neoplasms--mortality; Metallurgy--statistics & numerical data; Occupational Diseases--mortality; Occupational Exposure--adverse effects
Abstract
Background
The current study evaluates the mortality of 2,354 workers first employed at a Baltimore chromate production plant between 1950 and 1974.
Methods
The National Death Index (NDI Plus) was used to determine vital status and cause of death. Cumulative chromium (VI) exposure and nasal and skin irritation were evaluated as risk factors for lung cancer mortality.
Results
There are 91,186 person-years of observation and 217 lung cancer deaths. Cumulative chromium (VI) exposure, nasal irritation, nasal perforation, nasal ulceration, and other forms of irritation (e.g., skin irritation) were associated with lung cancer mortality.
Conclusion
Cumulative chromium (VI) exposure was a risk factor for lung cancer death. Cancer deaths, other than lung cancer, were not significantly elevated. Irritation may be a possible mechanism for chromium (VI)-induced lung cancer. Am. J. Ind. Med. © 2015 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
APA Citation
Gibb, H. J., Lees, P. S. J., Wang, J., & Grace O'Leary, K. (2015). Extended followup of a cohort of chromium production workers. American Journal of Industrial Medicine, 58(8), 905-913.
Peer Reviewed
1
Open Access
1
Comments
This article reproduced with permission of Wiley Online Library. American Journal of Industrial Medicine.