Integrase Strand Transfer Inhibitors and Weight Gain in Children and Youth with Perinatal Human Immunodeficiency Virus in the DC Cohort

Wei Li A. Koay, Childrens National Health System
Sahera Dirajlal-Fargo, CASE School of Medicine
Matthew E. Levy, Milken Institute School of Public Health
Paige Kulie, Milken Institute School of Public Health
Anne Monroe, Milken Institute School of Public Health
Amanda D. Castel, Milken Institute School of Public Health
Natella Y. Rakhmanina, Childrens National Health System
Lawrence D'Angelo, Childrens National Health System
Natella Rakhmanina, Childrens National Health System
Michael Kharfen, Childrens National Health System
Michael Serlin, Childrens National Health System
Princy Kumar, Childrens National Health System
Aria Bamdad, Childrens National Health System
Tsedenia Bezabeh, Childrens National Health System
Pamela Katzen Burrows, Childrens National Health System
Susan Reamer, Childrens National Health System
Alla Sapozhnikova, Childrens National Health System
Marinella Temprosa, Childrens National Health System
Naji Younes, Childrens National Health System
Morgan Byrne, Childrens National Health System
Amanda Castel, Childrens National Health System
Alan Greenberg, Childrens National Health System
Maria Jaurretche, Childrens National Health System
Matthew Levy, Childrens National Health System
Anne Monroe, Childrens National Health System
James Peterson, Childrens National Health System
Lindsey Powers Happ, Childrens National Health System
Brittany Wilbourn, Childrens National Health System
Yan Ma, Childrens National Health System
Hana Akselrod, Childrens National Health System
Ronald Wilcox, Childrens National Health System
Sohail Rana, Childrens National Health System

Document Type

Journal Article

Publication Date

7-1-2021

Journal

Open Forum Infectious Diseases

Volume

8

Issue

7

DOI

10.1093/ofid/ofab308

Keywords

adolescents; body mass index; HIV; integrase inhibitors; youth

Abstract

We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0-19 years) in the United States and report an increased rate of change of BMI-for-age z score after initiating integrase strand transfer inhibitors (+0.19 z score units/year [95% confidence interval,. 01-.37]; P=.036) for a median follow-up of 527.5 days.

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