PNPLA3; SAMM50; genome‐wide association study; liver cancer; nonalcoholic fatty liver disease
Background and Aim: Chronic hepatitis C virus (HCV) infection, long-term alcohol use, cigarette smoking, and obesity are the major risk factors for hepatocellular carcinoma (HCC) in the United States, but the disease risk varies substantially among individuals with these factors, suggesting host susceptibility to and gene-environment interactions in HCC. To address genetic susceptibility to HCC, we conducted a genome-wide association study (GWAS).
Methods: Two case-control studies on HCC were conducted in the United States. DNA samples were genotyped using the Illumian microarray chip with over 710 000 single nucleotide polymorphisms (SNPs). We compared these SNPs between 705 HCC cases and 1455 population controls for their associations with HCC and verified our findings in additional studies.
Results: In this GWAS, we found that two SNPs were associated with HCC at
Conclusions: SNPs in
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Wang, Z., Budhu, A., Shen, Y., Wong, L., Hernandez, B., Tiirikainen, M., Ma, X., Irwin, M., Lu, L., Zhao, H., Lim, J., Taddei, T., Mishra, L., Pawlish, K., Stroup, A., Brown, R., Nguyen, M., Koshiol, J., Hernandez, M., Forgues, M., Yang, H., Lee, M., Huang, Y., Iwasaki, M., Goto, A., Suzuki, S., Matsuda, K., Tanikawa, C., Kamatani, Y., Mann, D., Guarnera, M., Shetty, K., Thomas, C., Yuan, J., Khor, C., Koh, W., Risch, H., Wang, X., & Yu, H. (2021). Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study.. JGH Open, 5 (12). http://dx.doi.org/10.1002/jgh3.12682