A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients - An interim analysis
American Journal of Transplantation
Immunosuppression; Kidney transplant; Prospective; Śteroid-free
We compared three maintenance immunosuppressive regimens in a rapid discontinuation of prednisone protocol. From March 1, 2001, through December 31, 2003, 239 first and second kidney transplant recipients (166 LD; 73 DD) were randomized. All recipients were treated with Thymoglobulin; all received steroids intraoperatively and for 5 days postoperatively. Randomization was to cyclosporine-mycophenolate mofetil (n = 85); high-level tacrolimus (TAG) (8-12 ng/mL)-low-level sirolimus (SRL) (3-7 ng/mL) (n = 72); or low-level TAG (3-7 ng/mL)-high-level SRL (8-12 ng/mL) (n = 82). We found no difference at 24 months between groups in patient, graft, death-censored graft, or acute rejection-free graft survival, or in kidney function. Wound complications were more common in SRL-treated recipients (p = 0.02); we found no other differences between groups in complication rates. Our data suggest that excellent patient and graft survival and low rejection rates can be obtained using a variety of maintenance protocols without prednisone. Copyright © Blackwell Munksgaard 2005.
Kandaswamy, R., Melancon, J., Dunn, T., Tan, M., Casingal, V., Humar, A., Payne, W., Gruessner, R., Dunn, D., Najarian, J., Sutherland, D., Gillingham, K., & Matas, A. (2005). A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients - An interim analysis. American Journal of Transplantation, 5 (6). http://dx.doi.org/10.1111/j.1600-6143.2005.00885.x