Donor ethnicity influences outcomes following deceased-donor kidney transplantation in black recipients
Journal of the American Society of Nephrology
Although the majority of deceased-donor kidneys are donated after brain death, increased recovery of kidneys donated after cardiac death could reduce the organ shortage and is now a national priority. Racial disparities in donations after brain death have been well described for renal transplantation, but it is unknown whether similar disparities occur in donations after cardiac death. In this study, outcomes of adult deceased-donor renal transplant recipients included in the United Network for Organ Sharing database (1993 through 2006) were analyzed. Among black recipients of kidneys obtained after cardiac death, those who received kidneys from black donors had better long-term graft and patient survival than those who received kidneys from white donors. In addition, compared with standard-criteria kidneys from white donors after brain death, kidneys from black donors after cardiac death conferred a 70% reduction in the risk for graft loss (adjusted hazard ratio 0.30; 95% confidence interval 0.14 to 0.65; P = 0.002) and a 59% reduction in risk for death (adjusted hazard ratio 0.41; 95% confidence interval 0.2 to 0.87; P = 0.02) among black recipients. These findings suggest that kidneys obtained from black donors after cardiac death may afford the best long-term survival for black recipients. Copyright © 2008 by the American Society of Nephrology.
Locke, J., Warren, D., Dominici, F., Cameron, A., Leffell, M., McRann, D., Melancon, J., Segev, D., Simpkins, C., Singer, A., Zachary, A., & Montgomery, R. (2008). Donor ethnicity influences outcomes following deceased-donor kidney transplantation in black recipients. Journal of the American Society of Nephrology, 19 (10). http://dx.doi.org/10.1681/ASN.2008010078