Gene expression analysis in sinonasal polyposis before and after oral corticosteroids: A preliminary investigation

Authors

William E. Bolger, Uniformed Services University of the Health Sciences
Arjun S. Joshi, The George Washington University
Samuel Spear, Uniformed Services University of the Health Sciences
Michael Nelson, Walter Reed National Military Medical Center
Krishnamurthy Govindaraj, Uniformed Services University of the Health Sciences

Document Type

Journal Article

Publication Date

7-1-2007

Journal

Otolaryngology - Head and Neck Surgery

Volume

137

Issue

1

DOI

10.1016/j.otohns.2007.01.023

Abstract

Objective: To characterize gene expression in sinonasal polyps and to gain insight into change in expression after oral corticosteroid treatment. Study Design and Methods: Nasal polyps were obtained before and after oral corticosteroid treatment and gene expression was analyzed with a focused gene array technique. Results: Pretreated sinonasal polyps demonstrated high gene expression for chemokine and leukotriene receptor genes (CCR2, CCR5, CX3CL1, and LTB4R) in all patients. After treatment, the global effects of corticosteroids were evident on gene expression. Conclusions: Gene array techniques hold promise as a research method in sinonasal polyposis. The potential benefits, as well as the potential challenges, in using these research methods will be discussed. © 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation.

APA Citation

Bolger, W., Joshi, A., Spear, S., Nelson, M., & Govindaraj, K. (2007). Gene expression analysis in sinonasal polyposis before and after oral corticosteroids: A preliminary investigation. Otolaryngology - Head and Neck Surgery, 137 (1). http://dx.doi.org/10.1016/j.otohns.2007.01.023