Title

Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor

Document Type

Journal Article

Publication Date

1-1-2015

Journal

Pediatric Blood and Cancer

Volume

62

Issue

6

DOI

10.1002/pbc.25345

Keywords

ALK; Inflammatory myofibroblastic tumor; Second neoplasm; Wilms tumor

Abstract

© 2014 Wiley Periodicals, Inc. We report two survivors of Wilms tumor (WT) who developed inflammatory myofibroblastic tumor (IMT). The first patient had IMT in the mainstem bronchus 1 year after WT therapy that included vincristine, dactinomycin, doxorubicin (VDA) and whole lung radiation therapy (XRT). The second patient had IMT in the cecum 7 years after WT therapy consisting of VDA and abdominal XRT. The unlikely co-occurrence of WT and IMT suggests a genetic link between these tumors or that IMT can arise as a complication of cancer therapy. IMT should be considered in WT survivors who develop secondary tumors, especially at unusual sites.

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