Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor
Pediatric Blood and Cancer
ALK; Inflammatory myofibroblastic tumor; Second neoplasm; Wilms tumor
© 2014 Wiley Periodicals, Inc. We report two survivors of Wilms tumor (WT) who developed inflammatory myofibroblastic tumor (IMT). The first patient had IMT in the mainstem bronchus 1 year after WT therapy that included vincristine, dactinomycin, doxorubicin (VDA) and whole lung radiation therapy (XRT). The second patient had IMT in the cecum 7 years after WT therapy consisting of VDA and abdominal XRT. The unlikely co-occurrence of WT and IMT suggests a genetic link between these tumors or that IMT can arise as a complication of cancer therapy. IMT should be considered in WT survivors who develop secondary tumors, especially at unusual sites.
Ortiz, M., Rossi, C., Hill, D., Guzzetta, P., Qureshi, F., & Dome, J. (2015). Inflammatory myofibroblastic tumor as a second neoplasm after Wilms tumor. Pediatric Blood and Cancer, 62 (6). http://dx.doi.org/10.1002/pbc.25345