Title

Physiology of intra-abdominal and intrathoracic Nissen fundoplications in a porcine model

Document Type

Journal Article

Publication Date

1-1-2001

Journal

Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A

Volume

11

Issue

1

DOI

10.1089/10926420150502869

Abstract

Background: The physiologic competency of intrathoracic fundoplications remains controversial. This study compared the physiologic qualities of intra-abdominal Nissen fundoplications (IAF) with those of intrathoracic Nissen fundoplications (ITF) in a porcine model. Methods: The lower esophageal sphincter (LES) length (cm), LES resting pressure (mm Hg), and intragastric pressure (mm Hg) necessary to produce reflux or wrap distribution were manometrically assessed before and after IAF and ITF in 10 pigs. Mean ± SD were compared using analysis of variance. Results: There was no difference in LES length before and after IAF or ITF, but there was a significant increase in resting LES pressure after either IAF or ITF (P < 0.0001). In every fundoplication, physiologic intragastric pressures (<65 mm Hg) could not induce reflux, whereas supraphysiologic intragastric pressures resulted in wrap disruption of the most distal suture in every fundoplication, producing a full-thickness tear in the gastric wall. The amount of intragastric pressure necessary to disrupt either IAF or ITF was significantly greater than the intragastric pressures that produced reflux before fundoplication (P < 0.0001). However, there was no difference in intragastric pressures producing wrap disruption of IAF and ITF. Conclusions: Nissen fundoplications remain physiologically competent regardless of intra-abdominal or intrathoracic position.

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