Title

Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure

Document Type

Journal Article

Publication Date

8-1-2005

Journal

Digestive Diseases and Sciences

Volume

50

Issue

8

DOI

10.1007/s10620-005-2866-4

Keywords

Electrical stimulation; Gastrin; Lower esophageal sphincter; Motilin; Neurotensin; Pancreatic polypeptide; Stomach

Abstract

This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the greater curvature of the stomach. A sleeve device measured LES pressure before, during, and after GES, and regulatory peptides were measured during fasting and after a meal. A consistent and significant rise in LES pressure was observed during GES, and it was sustained after GES was discontinued. Plasma concentration and area under the curve of pancreatic polypeptide, motilin, gastrin and neurotensin were not affected by GES. We conclude that acute low- and high-frequency GES significantly increases LES pressure. This effect may not be modulated by efferent vagal activity or release of regulatory peptides. © 2005 Springer Science+Business Media, Inc.

This document is currently not available here.

Share

COinS