Title

The role of IGF-1R in pediatric malignancies

Document Type

Journal Article

Publication Date

3-9-2009

Journal

Oncologist

Volume

14

Issue

1

DOI

10.1634/theoncologist.2008-0189

Keywords

IGF-1R; Molecular targeting; Pediatric malignancy; Therapeutic antibody

Abstract

The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its activation, followed by signal transduction along several pathways. In some childhood malignancies, IGF-1R can be activated by endocrine, autocrine, or paracrine mechanisms. Although mutations in IGF-1R have not been identified, this signaling pathway is upregulated in many childhood cancers. These findings have led to the development of a host of IGF-1R signaling modulators that are currently being tested in clinical trials. This review explores the role of IGF-1R in a range of childhood malignancies. © AlphaMed Press.

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