Title

Semi-automatic segmentation of the placenta into fetal and maternal compartments using intravoxel incoherent motion MRI

Document Type

Conference Proceeding

Publication Date

1-1-2017

Journal

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volume

10137

DOI

10.1117/12.2254610

Keywords

DWI; GrowCut; IVIM; Placenta; Segmentation

Abstract

© 2017 SPIE. Intravoxel incoherent motion (IVIM) magnetic resonance imaging is an emerging non-invasive technique that has been recently applied to quantify in vivo global placental perfusion. We propose a robust semi-automated method for segmenting the placenta into fetal and maternal compartments from IVIM data, using a multi-label image segmentation algorithm called GrowCut'. Placental IVIM data were acquired on a 1.5T scanner from 16 healthy pregnant women between 21-37 gestational weeks. The voxel-wise perfusion fraction was then estimated after non-rigid image registration. The seed regions of the fetal and maternal compartments were determined using structural T2-weighted reference images, and improved progressively through an iterative process of the GrowCut algorithm to accurately encompass fetal and maternal compartments. We demonstrated that the placental perfusion fraction decreased in both fetal (-0.010/week) and maternal compartments (-0.013/week) while their relative difference (ffetal-fmaternal) gradually increased with advancing gestational age (+0.003/week, p=0.065). Our preliminary results show that the proposed method was effective in distinguishing placental compartments using IVIM.

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