Nutrition and the developing brain: the road to optimizing early neurodevelopment: a systematic review.
BACKGROUND: Neonatal intensive care practices have resulted in marked improvements in the survival of premature infants; however, they remain at significant risk for adverse neurodevelopmental outcomes. The impact of current nutritional practices on brain development following early extra-uterine exposure in premature infants is not well known.
METHODS: We performed a systematic review to investigate nutritional effects on postnatal brain development in healthy term and prematurely born infants utilizing advanced magnetic resonance imaging tools.
RESULTS: Systematic screen yielded 595 studies for appraisal. Of these, 22 total studies were selected for inclusion in the review, with findings summarized in a qualitative, descriptive fashion.
CONCLUSION: Fat and energy intake are associated with improved brain volume and development in premature infants. While breast milk intake and long-chain polyunsaturated fatty acid supplementation has been proven beneficial in term infants, the impact in preterm infants is less well understood.
Ottolini, K., Andescavage, N., Keller, S., & Limperopoulos, C. (2020). Nutrition and the developing brain: the road to optimizing early neurodevelopment: a systematic review.. Pediatric research, 87 (2). http://dx.doi.org/10.1038/s41390-019-0508-3