Pulsatile sinus pressure changes evoke sustained baroreflex responses in awake dogs
American Journal of Physiology - Heart and Circulatory Physiology
A modified Stephenson-Donald preparation was used to control pressure in an isolated carotid sinus in conscious dogs with all other arterial baroreceptors denervated. Sinus pressure was changed from preisolation control levels to either an elevated static or an elevated pulsatile pressure for 5 min. These sinus pressure changes evoked similar initial decreases in arterial pressure. The elevated static sinus pressure (150 or 175 mmHg) caused an initial depressor response of -32.7 ± 5.5 mmHg, which then decayed rapidly. Five minutes after the change in sinus pressure, the depressor response was abolished, as arterial pressure returned to control pressure. This decay of the response would be expected if resetting occurred. In contrast, when the sinus was exposed to elevated pulsatile pressures (125 or 150 mmHg mean, 50 mmHg pulse pressure) depressor responses were sustained throughout the sinus pressure change (-23.2 ± 5.3 mmHg initial, -29.0 ± 4.8 mmHg at 5 min; P > 0.4). These results demonstrate that while the reflex responses rapidly reset to elevated static sinus pressures, elevated pulsatile pressures elicit sustained reflex responses.
Mendelowitz, D., & Scher, A. (1988). Pulsatile sinus pressure changes evoke sustained baroreflex responses in awake dogs. American Journal of Physiology - Heart and Circulatory Physiology, 255 (3). Retrieved from https://hsrc.himmelfarb.gwu.edu/smhs_pharm_facpubs/877