Title

Heparan sulfates in the lung: structure, diversity, and role in pulmonary emphysema

Document Type

Journal Article

Publication Date

6-1-2010

Journal

Anat Rec (Hoboken)

Volume

293

Issue

6

Inclusive Pages

955-67

DOI

10.1002/ar.20895

Keywords

Animals; Heparitin Sulfate; Humans; Lung; Pulmonary Alveoli; Pulmonary Emphysema; Respiratory Mucosa

Abstract

There is an emerging interest in the extracellular matrix (ECM) of the lung, especially in the role it plays in development and disease. There is a rapid change from the classical view of the ECM as a supporting structure towards a view of the ECM as a regulatory entity with profound effects on proliferation, migration, and differentiation of pulmonary cells. In the ECM, a variety of molecules is present in a highly organized pattern. Next to the abundant fiber-forming molecules such as collagens and elastin, a large number of less abundant molecules are part of the ECM, including proteoglycans. In this review, we will focus on one class of proteoglycans, the heparan sulfate proteoglycans. We will particularly address the structure, biosynthesis, and function of their saccharide moiety, the heparan sulfates, including their role in development and (patho)physiology.

Peer Reviewed

1

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